The day you accept yourself with all your imperfections, you are no longer affected by the opinion, judgment, sarcasm and criticism of others. And that is the day when you are truly liberated!
They emphasize don't say Yes when you want to say NO.
I believe start saying YES even if your logical side says NO. Allow yourself to come out of your comfort zone, embrace the unknown with all it's pros and cons, start exploring new avenues and soon you'll find a New YOU!